(D-Trp7,Ala8,D-Phe10)-α-MSH (6-11) amide Melanocyte-Stimulating Hormone Catalog

CAS	87616-84-0
Sequence	H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Sequence Single	HwAWfK-NH2
Molecular Formula	C46H56N12O6
Molecular Weight	873.03
Synonyms	GHRP-6
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Obesity Research\|Pituitary & Hypothalamic Hormones
Description	(D-Trp7,Ala8,D-Phe10)-α-MSH (6-11) amide also called GHRP-6. In search of competitive α-MSH antagonists, the hexapeptide GHRP-6 has been recognized as a selective inhibitor of α-MSH activity in the frog skin bioassay. It is identical in sequence with a growth hormone-releasing peptide analog, (His1,Lys1)-GHRP, which selectively releases GH in vitro and in a wide variety of species in vivo. GHRP-6 also acts as a functional antagonist of somatostatin in the somatotrope cells.
References	1. Lysinoalanine as a metal chelator. An implication for toxicity. R.Hayashi, J. Biol. Chem., 257, 13896 (1982) 2. Binding of a growth hormone releasing hexapeptide to specific hypothalamic and pituitary binding sites. E.E.Codd et al., Neuropharmacology, 28, 1139 (1989) 3. Oral activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in rats, dogs and monkeys. R.F.Walker et al., Life Sci., 47, 29 (1990) 4. Discovery and structure-activity relationships of novel alpha-melanocyte-stimulating hormone inhibitors. T.K.Sawyer et al., Pept. Res., 2, 140 (1989) 5. Effect of D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102) on GH secretion in urethan-anesthetized rats. H.Sawada et al., Regul. Pept., 53, 195 (1994) 6. Arginine enhances the growth hormone-releasing activity of a synthetic hexapeptide (GHRP-6) in elderly but not in young subjects after oral administration. E.Ghigo et al., J. Endocrinol. Invest., 17, 157 (1994)

PeptideDB

(D-Trp7,Ala8,D-Phe10)-α-MSH (6-11) amide

CAS No.: 87616-84-0