PeptideDB

(Met(O)27)-Glucagon (1-29) (human, rat, porcine)

CAS No.: 75217-63-9

(Met(O)27)-Glucagon (1-29) shows the same maximal glucose mobilizing activity in rat hepatocytes as native glucagon, but
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CAS 75217-63-9
Sequence H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met(O)-Asn-Thr-OH
Sequence Single HSQGTFTSDYSKYLDSRRAQDFVQWLM(O)NT
Molecular Formula C153H225N43O50S
Molecular Weight 3498.8
Technology Synthetic
Storage -20°C, avoid light, cool and dry place
Application Diabetes
Description (Met(O)27)-Glucagon (1-29) shows the same maximal glucose mobilizing activity in rat hepatocytes as native glucagon, but it is less potent, suggesting a crucial role of methionine in the binding of glucagon to its hepatic receptor.
References 1.  Identification, localization and receptor characterization of novel mammalian substance P-like peptides. M.M.Kurtz et al., Gene, 296, 205 (2002)