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(Des-His1,Glu9)-Glucagon (1-29) amide (human, rat, porcine)

CAS No.: 110084-95-2

(Des-His1,Glu9)-Glucagon (1-29) amide (human, rat, porcine) is a potent and peptide antagonist of the glucagon receptor,
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CAS 110084-95-2
Sequence H-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2
Sequence Single SQGTFTSEYSKYLDSRRAQDFVQWLMNT-NH2
Molecular Formula C148H221N41O47S
Molecular Weight 3358.7
Technology Synthetic
Storage -20°C, avoid light, cool and dry place
Application Diabetes
Description (Des-His1,Glu9)-Glucagon (1-29) amide (human, rat, porcine) is a potent and peptide antagonist of the glucagon receptor, with a pA2 of 7.2. (Des-His1,Glu9)-Glucagon (1-29) amide (human, rat, porcine) is potentially useful in the study of the pathogenesis of diabetes.
References 1.  Isolation and characterization of the bovine hypothalamic growth hormone releasing factor. F.Esch et al., Biochem. Biophys. Res. Commun., 117, 772 (1983) 2.  Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. C.G.Unson et al., Peptides, 10, 1171 (1989)