Glucagon (19-29) (human, rat, porcine) Glucagons and Glucagon-Like Peptides Catalog

CAS	64790-15-4
Sequence	H-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH
Sequence Single	AQDFVQWLMNT
Molecular Formula	C61H89N15O18S
Molecular Weight	1352.53
Synonyms	Miniglucagon (human, rat, porcine)
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Diabetes
Description	Glucagon (19-29) (human, rat, porcine) also called Miniglucagon (human, rat, porcine), inhibited both the Ca2+ activated and Mg2+ dependent ATPase activity and Ca2+ transport in liver plasma membranes with an efficiency 1000-fold higher than that of glucagon. It is likely to be the active peptide involved in the inhibition of the liver Ca2+ pump. Miniglucagon, the ultimate processing product of proglucagon, is a regulator of the pancreatic islet physiology.
References	1. N-terminal galanin-(1-16) fragment is an agonist at the hippocampal galanin receptor. G.Fisone et al., Proc. Natl. Acad. Sci. USA, 86, 9588 (1989) 2. The glucagon-miniglucagon interplay: a new level in the metabolic regulation. D.Bataille et al., Ann. N. Y. Acad. Sci., 1070, 161 (2006) 3. A glucagon fragment is responsible for the inhibition of the liver Ca2+ pump by glucagon. A.Mallat et al., Nature, 325, 620 (1987) 4. Miniglucagon (glucagon 19-29): a novel regulator of the pancreatic islet physiology. S.Dalle et al., Diabetes, 51, 406 (2002)

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