| CAS | 720710-69-0 |
| Sequence | Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 |
| Sequence Single | Mca-KPLGL-Dpa-AR-NH2 |
| Molecular Formula | C55H80N16O16 |
| Molecular Weight | 1221.34 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research|Inflammation Research |
| Description | Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is the N-terminal elongation of the widely used MMP FRET substrate Mca-PLGL-Dpa-AR-NH2 with a Lys which yields a fluorogenic peptide with improved substrate properties. As compared to Mca-PLGL-Dpa-AR-NH2, the specificity constant (kcat/Km) of the broad-spectrum MMP-substrate Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 for collagenases (MMP-1, MMP-8, MMP-13) and MMP-14 is increased two- to ninefold and threefold, respectively, while those for gelatinases and matrilysin remain equally high. |
| References | 1. Protease-activated receptor 3 is a second thrombin receptor in humans. H.Ishihara et al., Nature, 386, 502 (1997) 2. Reduced amelogenin-MMP20 interactions in amelogenesis imperfecta. K.Tanimoto et al., J. Dent. Res., 87, 451 (2008) 3. Rapid determination of enzyme kinetics from fluorescence: overcoming the inner filter effect. M.O.Palmier and S.R.Van Doren, Anal. Biochem., 371, 43 (2007) |
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2
CAS No.: 720710-69-0
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is the N-terminal elongation of the widely used MMP FRET substrate Mca-PLGL
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