Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide Secretase Inhibitors and Substrates Catalog

CAS	438625-61-7
Sequence	Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2
Sequence Single	Mca-SEVNLDAEFRK(Dnp)-RR-NH2
Molecular Formula	C86H125N27O29
Molecular Weight	2001.1
Synonyms	Mca-(Asn670,Leu671)-APP770 (667-676)-Lys(Dnp)-Arg-Arg amide
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Alzheimer’s Disease
Description	Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide also called Mca-(Asn670,Leu671)-APP770 (667-676)-Lys(Dnp)-Arg-Arg amide, is fluorescent (FRET) peptide substrate containing the ‘Swedish’ Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVNLDAEFRK(Dnp)RR-amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo.
References	1. Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells. H.Koike et al., J. Biochem., 126, 235 (1999)

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