| CAS | 310427-94-2 |
| Sequence | H-Arg-Glu(EDANS)-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(DABCYL)-Arg-OH |
| Sequence Single | RE(EDANS)EVNLDAEFK(DABCYL)R |
| Molecular Formula | C91H129N25O25S |
| Molecular Weight | 2005.25 |
| Synonyms | Arg-Glu(EDANS)-(Asn670,Leu671)-APP770 (668-675)-Lys(DABCYL)-Arg |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease |
| Description | Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg also called Arg-Glu(EDANS)-(Asn670,Leu671)-APP770 (668-675)-Lys(DABCYL)-Arg, is a fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site EVNLDAEF of the Swedish mutation of APP. The kinetic parameters at pH 4.5 are Km = 5.4 µM and kcat = 0.24 min-1. |
| References | 1. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). T.Komatsu et al., J. Am. Chem. Soc., 135, 6002 (2013) |
Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg
CAS No.: 310427-94-2
Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg also called Arg-Glu(EDANS)-(
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