| CAS | 1802078-33-6 |
| Sequence | Mca-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2 |
| Sequence Single | Mca-SEVKMDAEFRK(Dnp)RR-NH2 |
| Molecular Formula | C87H129N27O28S |
| Molecular Weight | 2033.21 |
| Synonyms | Mca-APP770 (667-676)-Lys(Dnp)-Arg-Arg amide |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease |
| Description | Mca-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide also called Mca-APP770 (667-676)-Lys(Dnp)-Arg-Arg amide, is a fluorescent (FRET) peptide substrate containing the wild-type amyloid precursor protein (APP) β-secretase cleavage site. It has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo. |
| References | 1. Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: involvement of PAR-2 and non-PAR-2 mechanisms. H.Nishikawa et al., J. Pharmacol. Exp. Ther., 312, 324 (2005) |
Mca-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide
CAS No.: 1802078-33-6
Mca-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide also called Mca-APP770 (667-676)-Lys(Dnp)-Arg-Ar
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