| CAS | 135861-77-7 |
| Sequence | H-Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-OH |
| Sequence Single | LVVYPWTQR |
| Molecular Formula | C56H84N14O13 |
| Molecular Weight | 1161.37 |
| Synonyms | LVV-Hemorphin-6 (human), Spinorphin-Gln-Arg |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Opioid Research |
| Description | Leu-Valorphin-Arg also called LVV-Hemorphin-6 (human), Spinorphin-Gln-Arg, LVVYPWTQR, corresponds to the sequence (32-40) of the β-,δ-,γ-, and ε-chains of human hemoglobin. It shows binding affinity for µ- and sigma-opioid receptors and has opioid activity in the GPI bioassay. Leu-Valorphin-Arg is found in large amounts in the pituitary and seems to be present in the circulation to a much lesser degree. In view of its high stability towards the membrane-bound lung enzymes and its strong inhibitory action on ACE activity, Leu-Valorphin-Arg appears to be the most potent of the hemorphin-related peptides assayed. |