H-Tyr-L-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

CAS No.: 154121-70-7

H-Tyr-L-1,2,3,4-tetrahydroisoquinoline-3-carboxamide also called H-Tyr-Tic-NH2, H-Tyr-Tic-NH2 and its epimer are the fir

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CAS	154121-70-7
Sequence	H-Tyr-Tic-NH2
Sequence Single	Y-L-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Molecular Formula	C19H21N3O3
Molecular Weight	375.86
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Di- and Tripeptides
Description	H-Tyr-L-1,2,3,4-tetrahydroisoquinoline-3-carboxamide also called H-Tyr-Tic-NH2, H-Tyr-Tic-NH2 and its epimer are the first example for opioid peptides consisting of a message domain of only two residues. In addition, they are the first opioid dipeptides with significant opioid activity and represent a first meaningful link among peptide opioids and alkaloid opiates and thus may form the basis for an unified receptor site model. It has been shown furthermore that peptides containing the Tyr-Tic motif , as TIPP, act as very selective antagonists for δ-opioid receptors and those containing Tyr-D-Tic as non-selective μ-agonists.

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