| CAS | 205640-90-0 |
| Sequence | Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bonds between Cys6 and Cys12/Cys7 and Cys14) |
| Sequence Single | pEPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 |
| Molecular Formula | C152H243N47O44S4 |
| Molecular Weight | 3561.16 |
| Synonyms | Hypocretin-1 (human, mouse, rat), Orexin A, human, bovine, rat, mouse |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Obesity Research|Parkinson’s Disease |
| Description | Orexin A (human, mouse, rat) also called Hypocretin-1 (human, mouse, rat), Orexin A, human, bovine, rat, mouse, is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of orexin A to rats stimulated food consumption in a dose-dependent manner. The effect persisted at 4 h after injection, as orexin A seems to be resistant to peptidases. Orexin A specifically binds a G protein-coupled receptor, OX1R (IC50 = 20 nM to displace 50 % of radiolabeled orexin A bound to this receptor). Orexin A produced in the amygdala induces wakefulness and plays a role in the induction of human emotions. Narcolepsy has been associated with orexin deficiency. |
| References | 1. Inhibition of cathepsin B by its propeptide: use of overlapping peptides to identify a critical segment. J.R.Chagas et al., FEBS Lett., 392, 233 (1996) 2. Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction. A.M.Blouin et al., Nat. Commun., 4, 1547 (2013) 3. Orexin-A inhibits glucagon secretion and gene expression through a Foxo1-dependent pathway. E.Göncz et al., Endocrinology, 149, 1618 (2008) 4. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. M.R.Jain et al., Regul. Pept., 87, 19 (2000) 5. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. T.Sakurai et al., Cell, 92, 573 (1998) |