| CAS | 1061556-49-7 |
| Sequence | H-Ala-Phe-Cys-Asn-Leu-Arg-Dab-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2(Disulfide bridges: 3-21, 8-26, 12-28) |
| Sequence Single | AFCNLR-Dab-CQLSCRSLGLLGKCIGDKCECVKH-NH2(Disulfide bridges: 3-21, 8-26, 12-28) |
| Molecular Formula | C141H236N46O39S6 |
| Molecular Weight | 3392.06 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a Kd of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels. |
| References | 1. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. Shakkottai et al (2001). J.Biol.Chem. 276 43145 PMID: 11527975 2. A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor. Kramar et al (2004). J.Neurosci. 24 5151 PMID: 15175384 3. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Kasumu et al (2012). Chem.Biol. 19 1340 PMID: 23102227 |