| CAS | 2376255-48-8 |
| Sequence | Ac-Phe-Leu-Thr-Asp-CMK |
| Sequence Single | Ac-FLTD-CMK |
| Molecular Formula | C26H37ClN4O8 |
| Molecular Weight | 569.05 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3. |
| References | 1. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Yang et al (2018). Proc.Natl.Acad.Sci.U.S.A. 115 6792 PMID: 29891674 |