| CAS | 24345-16-2 |
| Sequence | H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2(Disulfide bridges: 1-11, 3-15) |
| Sequence Single | CNCKAPETALCARRCQQH-NH2(Disulfide bridges: 1-11, 3-15) |
| Molecular Formula | C79H131N31O24S4 |
| Molecular Weight | 2027.34 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity. |
| References | 1. Apamin. Habermann (1984). Pharmacol.Ther. 25 255 PMID: 6095335 2. Matching molecules to function: neuronal Ca2+-activated K+ channels and afterhyperpolarizations. Stocker et al (2004). Toxicon 43 933 PMID: 15208027 3. Potassium channel toxins. Strong (1990). Pharmacol.Ther. 46 137 PMID: 2181489 4. Behavioral effects of apamin, a selective inhibitor of the SKCa-channel, in mice and rats. van der Staay et al (1999). Neurosci.Biobehav.Rev. 23 1087 PMID: 10643819 |