| CAS | 70904-56-2 |
| Sequence | H-Tyr-Arg-OH |
| Sequence Single | YR |
| Molecular Formula | C15H23N5O4 |
| Molecular Weight | 337.38 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cosmetic Peptides & Dermatology|Di- and Tripeptides|Opioid Research |
| Description | Kyotorphin is an endogenou neuroactive dipeptide with analgesic properties. Kyotorphin possesses anti-inflammatory and antimicrobial activity. Administered intracisternally to mice, kyotorphin had an analgesic effect which was about 4.2 times more potent than that of Met-enkephalin. Kyotorphin levels in cerebro-spinal fluid correlate negatively with the progression of neurodegeneration in Alzheimer’s Disease patients. |
| References | 1. Post-proline dipeptidyl-aminopeptidase from synaptosomal membranes of guinea-pig brain. A possible role for this activity in the hydrolysis of His-ProNH2, arising from the action of synaptosomal membrane pyroglutamate aminopeptidase on thyroliberin. B.O’Connor and G.O’Cuinn, Eur. J. Biochem., 154, 329 (1986) 2. Comparison of the analgesic effects of various opioid peptides by a newly devised intracisternal injection technique in conscious mice. H.Ueda et al., Eur. J. Pharmacol., 56, 265 (1979) 3. A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser. H.Takagi et al., Nature, 282, 410 (1979) 4. Morphine-like analgesia by a new dipeptide, L-tyrosyl-L-arginine (Kyotorphin) and its analogue. H.Takagi et al., Eur. J. Pharmacol., 55, 109 (1979) 5. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. K.Lintner and O.Peschar, Int. J. Cosmet. Sci., 22, 207 (2000) 6. Stimulation of Na+/Cl--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2. S.V.Thakkar et al., Drug Metab. Pharmacokinet., 23, 254 (2008) |