| CAS | 142479-62-7 |
| Sequence | H-Tyr-Pro-Ile-Ser-Leu-OH |
| Sequence Single | YPISL |
| Molecular Formula | C29H45N5O8 |
| Molecular Weight | 591.71 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Opioid Research |
| Description | Gluten Exorphin C, isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten, was considered as a δ-opioid receptor-selective ligand. The hydrophobicity of Ile3 seems to be important for the expression of the opioid activity of gluten exorphin C. Moreover, this peptide appears to be quite different from any of the endogenous and exogenous opioid peptides ever reported as the N-terminal Tyr is the only aromatic amino acid in the structure. Its IC50 values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively. |
| References | 1. CD36 peptides enhance or inhibit CD36-thrombospondin binding. A two-step process of ligand-receptor interaction. L.L.K.Leung et al., J. Biol. Chem., 267, 18244 (1992) 2. Opioid peptides derived from food proteins. The exorphins. C.Zioudrou et al., J. Biol. Chem., 254, 2446 (1979) 3. Demonstration of high opioid-like activity in isolated peptides from wheat gluten hydrolysates. F.R.Huebner et al., Peptides, 5, 1139 (1984) 4. Gluten exorphin C. A novel opioid peptide derived from wheat gluten. S.Fukudome et al., Peptide Chemistry 1991, A.Suzuki, ed., Protein Research Foundation, Osaka, p. 345, (1992) 5. Gluten exorphin C. A novel opioid peptide derived from wheat gluten. Fukudome S, et al. FEBS Lett. 1993 Jan 18;316(1):17-9. |