| CAS | 676657-00-4 |
| Sequence | H-Lys-Tyr-Leu-Pro-Tyr-Trp-Pro-Val-Leu-Ser-Ser-Leu-OH |
| Sequence Single | KYLPYWPVLSSL |
| Molecular Formula | C74H108N14O17 |
| Molecular Weight | 1465.75 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | KYL is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); KYL inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). KYL prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. KYL exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively). KYL is neuroprotective. |
| References | 1. Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Lamberto et al (2012). Biochem. J. 445 47 PMID: 22489865 2. EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. Vargas et al (2014). PLoS One. 9 e92309 PMID: 24658113 |