| CAS | 1236188-16-1 |
| Sequence | H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-pTyr-Met-Asp-Met-Ser-OH |
| Sequence Single | RQIKIWFQNRRMKWKKSDGG-pTyr-MDMS |
| Molecular Formula | C141H222N43O39PS3 |
| Molecular Weight | 3270.72 |
| Synonyms | PDGFR740Y-P |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | 740 Y-P also called PDGFR740Y-P, is a cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro. |
| References | 1. Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Williams and Doherty (1999). Mol.Cell.Neurosci. 13 272 PMID: 10328886 2. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Derossi D, et al. Biochem Biophys Res Commun. 1998 Oct 9;251(1):148-52. 3. Graphene Oxide Induces p62/SQSTM-dependent Apoptosis Through the Impairment of Autophagic Flux and Lysosomal Dysfunction in PC12 Cells. Xiaoli Feng, et al. Acta Biomater. 2018 Nov;81:278-292. 4. GABAB Receptor-Mediated PI3K/Akt Signaling Pathway Alleviates Oxidative Stress and Neuronal Cell Injury in a Rat Model of Alzheimer’s Disease. Zhiqing Sun, et al. J Alzheimers Dis. 2020;76(4):1513-1526. |