| CAS | 1207610-07-8 |
| Sequence | N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-Leu-Asp-Val-Pro-Ala-Ala-Lys(FITC)-OH |
| Sequence Single | N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-LDVPAAK(FITC) |
| Molecular Formula | C69H81N11O17S |
| Molecular Weight | 1368.54 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | LDV FITC is a fluorescent ligand that binds to the α4β1 integrin (VLA-4) with high affinity (Kd values are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). LDV FITC is used to detect VLA-4 affinity and conformational changes. |
| References | 1. Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn2+ or antibody activation. A Chigaev et al (2001). J.Biol.Chem. 276 48670 PMID: 11641394 2. Conformational mAb as a tool for integrin ligand discovery. Njus et al (2009). Assay Drug Dev.Technol. 7 507 PMID: 19754304 3. FRET detection of cellular α4-integrin conformational activation. Chigaev et al (2003). Biophys.J. 85 3951 PMID: 14645084 |