| CAS | 374675-18-0 |
| Sequence | H-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Sequence Single | LPNYNWNSFGLRF-NH2 |
| Molecular Formula | C78H107N21O18 |
| Molecular Weight | 1626.84 |
| Synonyms | Malignant Melanoma Metastasis-Suppressor KiSS-1 (109-121) (human), KiSS-1 (109-121) (human), Metastin (42-54) (human), Kisspeptin-14 (2-14) (human), Kisspeptin-54 (42-54) (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research |
| Description | Kisspeptin-13 (human) also called Malignant Melanoma Metastasis-Suppressor KiSS-1 (109-121) (human), KiSS-1 (109-121) (human), Metastin (42-54) (human), Kisspeptin-14 (2-14) (human), Kisspeptin-54 (42-54) (human), is an LRF-amide motif containing fragment of malignant melanoma metastasis suppressor KiSS-1. It bound with low nanomolar affinity to the rat and human G protein-coupled receptor GPR54 expressed in Chinese hamster ovary K1 cells and stimulated PIP2 hydrolysis, Ca2+ mobilization, arachidonic acid release, ERK1/2 and p38 MAP kinase phosphorylation, and stress fiber formation but inhibited cell proliferation. |
| References | 1. Activities of synthetic hybrid peptides against anaerobic bacteria: aspects of methodology and stability. H.Oh et al., Antimicrob. Agents Chemother., 44, 68 (2000) 2. Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas. R.A.Silvestre et al., J. Endocrinol., 196, 283 (2008) |