| CAS | 171492-13-0 |
| Sequence | H-Phe-Glu-Trp-Thr-Pro-Gly-Tyr-Trp-Gln-Pro-Tyr-Ala-Leu-Pro-Leu-OH |
| Sequence Single | FEWTPGYWQPYALPL |
| Molecular Formula | C95H122N18O22 |
| Molecular Weight | 1868.12 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cytokines/Chemokines & their Receptors |
| Description | AF11377 is a peptide with the sequence of FEWTPGYWQPYALPL, it blocked IL-1α-binding to the type I IL-1 receptor with IC50 = 1.9 nM. AF11377 blocked IL-1-driven responses in human and monkey cells. This is the first example of a high affinity peptide that binds to a cytokine receptor and acts as a cytokine antagonist. |