| CAS | 374675-21-5 |
| Sequence | H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Sequence Single | YNWNSFGLRF-NH2 |
| Molecular Formula | C63H83N17O14 |
| Molecular Weight | 1302.46 |
| Synonyms | Kisspeptin-10, Malignant Melanoma Metastasis-Suppressor KiSS-1 (112-121) (human), KiSS-1 (112-121) (human), Metastin (45-54) (human), Kisspeptin-14 (5-14) (human), Kisspeptin-54 (45-54) (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research |
| Description | Kisspeptin-13 (4-13) (human) also called Kisspeptin-10, Malignant Melanoma Metastasis-Suppressor KiSS-1 (112-121) (human), KiSS-1 (112-121) (human), Metastin (45-54) (human), Kisspeptin-14 (5-14) (human), Kisspeptin-54 (45-54) (human), is an LRF-amide motif containing fragment of malignant melanoma metastasis suppressor KiSS-1. It shows high agonistic potency towards the human G-protein-coupled receptor GPR54 also known as AXOR12. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression. |
| References | 1. AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. A.I.Muir et al., J. Biol. Chem., 276, 28969 (2001) 2. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J.T.George et al., J. Clin. Endocrinol. Metab., 96, E1228 (2011) 3. Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1). A.West et al., Genomics, 54, 145 (1998) 4. Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Son HE, et al. Sci Rep. 2018 Feb 1;8(1):2134. |