| CAS | 434938-41-7 |
| Sequence | D-Phe-His-Leu-Leu-Arg-Lys-Nle-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2 |
| Sequence Single | D-Phe-HLLRK-Nle-IEIEKQEKEKQQAANNRLLLDTI-NH2 |
| Molecular Formula | C162H276N48O46 |
| Molecular Weight | 3632.26 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | K 41498 is a potent and highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively. K 41498 is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. K 41498 can be used for hypotension study. |
| References | 1. Design, synthesis and pharmacological characterization of new highly selective CRF2 antagonists: development of 123I-K31440 as a potential SPECT ligand. Ruhmann et al (2002). Peptides 23 453 PMID: 11835994 2. The highly selective CRF2 receptor antagonist K41498 binds to presynaptic CRF2 receptors in rat brain. Lawrence et al (2002). Br.J.Pharmacol. 136 896 PMID: 12110614 |