| CAS | 222018-18-0 |
| Sequence | Octadecanoyl-Tyr-Gly-Tyr-Arg-Leu-Arg-Arg-Lys-Trp-Glu-Glu-Lys-Ile-Pro-Asn-Pro-NH2 |
| Sequence Single | Octadecanoyl-Tyr-GYRLRRKWEEKIPNP-NH2 |
| Molecular Formula | C115H184N30O24 |
| Molecular Weight | 2370.91 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Lyn peptide inhibitor is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor can be used for study of asthma, allergic, and other eosinophilic disorders. |
| References | 1. The mapping of the Lyn kinase binding site of the common β subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. Adachi et al (1999). J.Immunol. 162 1496 PMID: 9973406 2. A novel lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. Adachi et al (1999). J.Immunol. 163 939 PMID: 10395690 |