| CAS | 681260-70-8 |
| Sequence | Ac-Asp-Leu-Ser-D-Phe-His-α-methyl-Leu-Leu-Arg-Lys-Nle-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-γ-Glu-Asn-Asn-ε-Lys-Leu-Leu-Leu-Asp-α-methyl-Leu-Ile-OH (Lactam Bridge = Glu-24 - Lys-27) |
| Sequence Single | Ac-DLS-D-Phe-H-α-methyl-Leu-LRK-Nle-IEIEKQEKEKQQA-γ-Glu-NN-ε-Lys-LLLD-α-methyl-Leu-I (Lactam Bridge = Glu-24 - Lys-27) |
| Molecular Formula | C183H307N49O53 |
| Molecular Weight | 4041.69 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively). Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying. |
| References | 1. Potent and long-acting cortico. releasing factor (CRF) receptor 2 selective peptide competitive antagonists. Rivier et al (2002). J.Med.Chem. 45 4737 PMID: 12361401 2. Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupled sensitivity and determinants of CRF2 receptor selectivity. Hoare et al (2005). Peptides 26 457 PMID: 15652653 3. The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. Henry et al (2006). J.Neurosci. 26 9142 PMID: 16957071 |