| CAS | 129203-60-7 |
| Sequence | Pyr-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH (Disulfide bonds between Cys7 and Cys28/Cys13 and Cys33/Cys17 and Cys35) |
| Sequence Single | pEFTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ |
| Molecular Formula | C179H274N50O55S7 |
| Molecular Weight | 4230.91 |
| Synonyms | IbTx |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Ion Channel Modulating Agents |
| Description | Iberiotoxin also called IbTx, is a peptide from the venom of the scorpion Buthus tamulus, it shows 68% sequence homology with charybdotoxin, another scorpion-derived peptidyl toxin. Although these two toxins both inhibit the high conductance Ca2+ activated K+ channel, they appear to bind at different sites on the channel and modulate channel activity by different mechanisms. Thus, iberiotoxin can be used to selectively study the function of the high conductance Ca2+ activated K+ channel. |
| References | 1. HIV-1 protease: characterization of a catalytically competent enzyme-substrate intermediate. D.J.Porter et al., Biochemistry, 41, 1302 (2002) 2. Interaction of iberiotoxin with beta-adrenoceptor agonists and sodium nitroprusside on guinea pig trachea. T.R.Jones et al., J. Appl. Physiol., 74, 1879 (1993) 3. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. A.Galvez et al., J. Biol. Chem., 265, 11083 (1990) 4. Activation of BK Channel Contributes to PL-Induced Mesenchymal Stem Cell Migration. Santiago Echeverry, et al. Front Physiol. 2020 Mar 24;11:210. 5. Mode of Action of Iberiotoxin, a Potent Blocker of the Large Conductance Ca(2+)-activated K+ Channel. S Candia, et al. Biophys J. 1992 Aug;63(2):583-90. 6. Downregulation of Large Conductance Calcium-Activated Potassium Channels in Paraventricular Nucleus Contributes to Sympathoexcitation in Rats With Chronic Heart Failure. R J Wang, et al. Zhonghua Xin Xue Guan Bing Za Zhi. 2018 Mar 24;46(3):178-186. |