| CAS | 330936-69-1 |
| Sequence | H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH |
| Sequence Single | MAPRGFSCLLLLTSEIDLPVKRRA |
| Molecular Formula | C119H204N34O32S2 |
| Molecular Weight | 2687.27 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease |
| Description | Humanin (HN) is a polypeptide suppressing neuronal cell death induced by several familial Alzheimer’s disease genes and by amyloid β-protein (1-43) (human). It has been shown that amyloid β-protein (1-40) and amyloid β-protein (1-42) secretion is not affected by humanin in F11 cells expressing the familial Alzheimer’s disease gene K595N/M596L-APP. Inhibitory actions on neuronal cell death triggered by K595N/M596L-APP directly and caused by amyloid β-protein have been suggested. |
| References | 1. Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties. I.Kaneko, J. Neurochem., 68, 438 (1997) 2. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer’s disease genes and Abeta. B.Zapala et al., Pharmacol. Rep., 62, 767 (2010) 3. Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein. Y.Hashimoto et al., Proc. Natl. Acad. Sci. USA, 98, 6336 (2001) 4. Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties. Y.Hashimoto et al., Biochem. Biophys. Res. Commun., 283, 460 (2001) |