| CAS | 330936-70-4 |
| Sequence | H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH |
| Sequence Single | MAPRGFSCLLLLTGEIDLPVKRRA |
| Molecular Formula | C118H202N34O31S2 |
| Molecular Weight | 2657.25 |
| Synonyms | S14G-Humanin (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease |
| Description | (Gly14)-Humanin (human) also called S14G-Humanin (human), is a more potent neuroprotective factor than native humanin. In middle-aged APPswe/PS1dE9 mice, the mutant peptide (Gly14)-Humanin (human) improved cognitive deficits and reduced amyloid pathology. S14G-Humanin inhibited Aβ 1-42 fibril formation, disaggregates preformed fibrils, and protects against Abeta-induced cytotoxicity in vitro. |
| References | 1. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer’s disease genes and Abeta. Y.Hashimoto et al., Proc. Natl. Acad. Sci. USA, 98, 6336 (2001) 2. S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice. W.Zhang et al., Pharmacol. Biochem. Behav., 100, 361 (2012) 3. S14G-humanin inhibits Aβ1-42 fibril formation, disaggregates preformed fibrils, and protects against Aβ-induced cytotoxicity in vitro. W.Zhang et al., J. Pept. Sci., 19, 159 (2013) 4. A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. T.Niikura et al., PLoS One, 6, e16259 (2011) 5. S14G-Humanin ameliorates Abeta25-35-induced behavioral deficits by reducing neuroinflammatory responses and apoptosis in mice. J.Miao et al., Neuropeptides, 42, 557 (2008) 6. Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties. B.Zapala et al., Pharmacol. Rep., 62, 767 (2010) |