H-Glu-Leu-Asp-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]-Ala-Glu-Phe-OH Secretase Inhibitors and Substrates Catalog

CAS No.: 1349991-28-1

H-Glu-Leu-Asp-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]-Ala-Glu-Phe-OH (ELD[(2R,4S,5S)-5-amino-4-hydroxy-2,7-

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CAS	1349991-28-1
Sequence	H-Glu-Leu-Asp-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]-Ala-Glu-Phe-OH
Sequence Single	ELD[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]AEF
Molecular Formula	C42H65N7O15
Molecular Weight	908.02
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Alzheimer’s Disease
Description	H-Glu-Leu-Asp-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]-Ala-Glu-Phe-OH (ELD[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyl-octanoyl]AEF), is a potent inhibitor for human brain memapsin-2 (β-secretase) with a Ki-value of 0.3 nM. The hydroxyethylene isostere of the Leu-Ala motif functions as a mimic of the transition state.

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