| CAS | 148505-03-7 |
| Sequence | H-Trp-Lys-Lys-Glu-Leu-Arg-Asp-Ala-Tyr-Arg-Glu-Ala-Gln-Gln-Leu-Val-Gln-Arg-Val-Pro-Lys-Met-Lys-Asn-Lys-Pro-Arg-Ser-OH |
| Sequence Single | WKKELRDAYREAQQLVQRVPKMKNKPRS |
| Molecular Formula | C153H256N50O41S |
| Molecular Weight | 3484.08 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | GRK2i is a GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. GRK2i corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist. |
| References | 1. Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling. Koch et al (1994). J.Biol.Chem. 269 6193 PMID: 8119963 2. A βγ dimer derived from G13 transduces the angiotensin AT1 receptor signal to stimulation of Ca2+ channels in rat portal vein myocytes. Macrez et al (1997). J.Biol.Chem. 272 23180 PMID: 9287322 3. Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons. Dang et al (2009). J.Neurosci. 29 3322 PMID: 19279269 4. Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction. Jorge A Sierra-Fonseca, et al. BMC Neurosci. 2014 Dec 31;15:132. |