| CAS | 340821-13-8 |
| Sequence | H-D-Phe-Cys-Phe-N-Me-D-Trp-Lys-Thr-Cys-Thr-NH2 (Disulfide bond) |
| Sequence Single | fCF-N-Me-wKTCT-NH2 (Disulfide bond) |
| Molecular Formula | C50H67N11O10S2 |
| Molecular Weight | 1046.28 |
| Synonyms | (N-Me-D-Trp4,Thr8)-Octreotide amide, (N-Me-D-Trp4)-Octreotate amide |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research |
| Description | (D-Phe5,Cys6.11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide also called (N-Me-D-Trp4,Thr8)-Octreotide amide, (N-Me-D-Trp4)-Octreotate amide, is a synthetic somatostatin analog. It is selective for the human somatostatin receptor subtype 5 (hsst5) with a binding affinity similar to somatostatin-28. Its Kd +/-SEM values for hsst1, hsst2, hsst3, hsst4, and hsst5 are 1200 nM, 23.5 +/- 3.92 nM, 11.05 +/- 1.03 nM, > 1000 nM, and 0.61 +/- 0.36 nM, respectively. Due to its selectivity it might prove to be useful for evaluating hsst5-mediated responses. |
| References | 1. Development of a synthetic cyclized peptide derived from alpha-fetoprotein that prevents the growth of human breast cancer. F.B.Mesfin et al., J. Pept. Res., 58, 246 (2001) |
(D-Phe5,Cys6.11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide
CAS No.: 340821-13-8
(D-Phe5,Cys6.11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide also called (N-Me-D-Trp4,Thr8)-Octreotide amide, (N-Me-D-Trp4)
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