| CAS | 58976-46-8 |
| Sequence | H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bond) |
| Sequence Single | AGCKNFFwKTFTSC |
| Molecular Formula | C76H104N18O19S2 |
| Molecular Weight | 1637.9 |
| Synonyms | [DTrp8] Somatostatin |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Gastrointestinal Research|Pituitary & Hypothalamic Hormones |
| Description | (D-Trp8)-Somatostatin-14 also called [DTrp8] Somatostatin, is a somatostatin analog. It is 6-8 times more potent than somatostatin in inhibiting the release of growth hormone, glucagon, and insulin. It may better resist degradation by biological fluids. |
| References | 1. Thrombin receptor agonist peptide decreases thrombomodulin activity in cultured human umbilical vein endothelial cells. Y.Maruyama et al., Biochem. Biophys. Res. Commun., 199, 1262 (1994) 2. D-Trp8-somatostatin: an analog of somatostatin more potent than the native molecule. J.Rivier et al., Biochem. Biophys. Res. Commun., 65, 746 (1975) 3. Differential internalization of somatostatin in COS-7 cells transfected with SST1 and SST2 receptor subtypes: a confocal microscopic study using novel fluorescent somatostatin derivatives. D.Nouel et al., Endocrinology, 138, 296 (1997) |