| CAS | 111857-96-6 |
| Sequence | H-D-2-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-2-Nal-NH2 (Disulfide bond) |
| Sequence Single | D-2-Nal-CYwKVC-2-Nal-NH2 |
| Molecular Formula | C63H73N11O9S2 |
| Molecular Weight | 1192.47 |
| Synonyms | (D-2-Nal5,Cys6.11,Tyr7,D-Trp8,Val10,2-Nal12)-Somatostatin-14 (5-12) amide, DC-13-217, DNal-Cys-Tyr-DTrp-Lys-Val-Cys-Nal-NH2 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research |
| Description | BIM-23042 also called (D-2-Nal5,Cys6.11,Tyr7,D-Trp8,Val10,2-Nal12)-Somatostatin-14 (5-12) amide, DC-13-217, DNal-Cys-Tyr-DTrp-Lys-Val-Cys-Nal-NH2, functions as neuromedin B receptor antagonist (IC50 = 885 ± 98 nM). It displays a > 100-fold higher selectivity for neuromedin B versus gastrin-releasing peptide receptors. |
| References | 1. O-phospho-L-tyrosine protects TP53 wild-type cells against ionizing radiation. K.H.Dittmann et al., Int. J. Cancer, 96 Suppl., 1 (2001) 2. Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues. M.Orbuch et al., Mol. Pharmacol., 44, 841 (1993) |