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(d(CH2)5¹,Tyr(Me)2,Thr4,Orn8,Tyr-NH2⁹)-Vasotocin

CAS No.: 114056-26-7

(d(CH2)5¹,Tyr(Me)2,Thr4,Orn8,Tyr-NH2⁹)-Vasotocin also called OVTA, Vasotocin analog, is a oxytocin antagonist, it show
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CAS 114056-26-7
Sequence β-Mercapto-β,β-cyclopentamethylene-propionyl-Tyr(Me)-Ile-Thr-Asn-Cys-Pro-Orn-Tyr-NH2 (Disulfide bond)
Sequence Single β-Mercapto-β,β-cyclopentamethylene-propionyl-Y(Me)-ITNCP-Orn-Y-NH2(Disulfide bond)
Molecular Formula C54H79N11O13S2
Molecular Weight 1154.42
Synonyms OVTA, Vasotocin analog
Technology Synthetic
Storage -20°C, avoid light, cool and dry place
Application Pituitary & Hypothalamic Hormones
Description (d(CH2)5¹,Tyr(Me)2,Thr4,Orn8,Tyr-NH2⁹)-Vasotocin also called OVTA, Vasotocin analog, is a oxytocin antagonist, it shows enhanced affinity for rat uterine oxytocin receptors after iodination.
References 1.  Muramylpeptides and lipopeptides: Studies towards immunostimulants. G.Baschang, Tetrahedron, 45, 6331 (1989) 2.  Up-regulation of mesotocin receptors in the tammar wallaby myometrium is pregnancy-specific and independent of estrogen. A.L.Siebel et al., Biol. Reprod., 66, 1237 (2002) 3.  125I-labelled d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH2(9)]OVT: a selective oxytocin receptor ligand. J.Elands et al., Eur. J. Pharmacol., 147, 197 (1988)