| CAS | 84211-54-1 |
| Sequence | Cyclo(-7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)) |
| Sequence Single | Cyclo(-7-aminoheptanoyl-DwKT(Bzl)) |
| Molecular Formula | C44H57N7O6 |
| Molecular Weight | 779.98 |
| Synonyms | Somatostatin Antagonist |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research |
| Description | Cyclo-Somatostatin is a potent somatostatin (SST) receptor antagonist. Cyclo-Somatostatin can inhibit somatostatin receptor type 1 (SSTR1) signaling and decreases cell proliferation, ALDH+ cell population size and sphere-formation in colorectal cancer (CRC) cells. |
| References | 1. 1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive. L.A.Carpino, J. Am. Chem. Soc., 115, 4397 (1993) 2. Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells. Shirin R Modarai, et al. BMC Cancer. 2016 Dec 7;16(1):941. |