| CAS | 103429-31-8 |
| Sequence | H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (Disulfide bond) |
| Sequence Single | fCYw-Orn-T-Pen-T-NH2(Disulfide bond) |
| Molecular Formula | C50H67N11O11S2 |
| Molecular Weight | 1062.28 |
| Synonyms | (Tyr3,Orn5,Pen7)-Octreotate amide, NTB (Naltriben) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Opioid Research |
| Description | CTOP also called (Tyr3,Orn5,Pen7)-Octreotate amide, NTB (Naltriben), is a potent and highly selective μ-opioid receptor antagonist. CTOP antagonizes the acute morphine-induced analgesic effect and hypermotility. CTOP enhances extracellular dopamine levels in the nucleus accumbens. CTOP dose-dependently enhances locomotor activity. |
| References | 1. Cloning, purification, and enzymatic properties of dipeptidyl peptidase IV from the swine pathogen Streptococcus suis. M.-C.Jobin et al., J. Bacteriol., 187, 795 (2005) 2. [3H]-[H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2] ([3H]CTOP), a potent and highly selective peptide for mu opioid receptors in rat brain. K.N.Hawkins et al., J. Pharmacol. Exp. Ther., 248, 73 (1989) 3. Intra-VTA injections of the mu-opioid antagonist CTOP enhance locomotor activity. Badiani et al (1995). Brain Res. 690 112 PMID: 7496796 4. Central effects of the potent and highly selective mu opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice. Gulya et al (1988). Eur.J.Pharmacol. 150 355 PMID: 2901358 5. [3H]-[H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2] ([3H]CTOP), a potent and highly selective peptide for mu opioid receptors in rat brain. Hawkins et al (1989). J.Pharmacol.Exp.Ther. 248 73 PMID: 2563293 6. The μ-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) [but not D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP)] produces a no Mol. Chieng et al (1996). Pharmacol. 50 650 PMID: 8794906 |