| CAS | 38916-34-6 |
| Sequence | H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bond) |
| Sequence Single | AGCKNFFWKTFTSC |
| Molecular Formula | C76H104N18O19S2 |
| Molecular Weight | 1637.9 |
| Synonyms | Somatotropin Release-Inhibiting Factor, SRIF, SRIF-14 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research|Gastrointestinal Research|Pituitary & Hypothalamic Hormones |
| Description | Somatostatin-14 also called Somatotropin Release-Inhibiting Factor, SRIF, SRIF-14, was originally isolated from ovine hypothalamic extracts on the basis of its ability to inhibit the secretion of radioimmunoassayable growth hormone by primary cultures of enzymatically dispersed rat anterior pituitary cells. Somatostatin-14 is a small cyclic neuropeptide hormone with broad inhibitory effects on endocrine secretions such as the production of GH, glucagon, and insulin. Somatostatin-14 inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. |
| References | 1. D-penicillamine in systemic sclerosis? Yes! T.A.Medsger Jr. et al., Scand. J. Rheumatol., 30, 192 (2001) 2. Spontaneous fibrillation of the native neuropeptide hormone Somatostatin-14. W.van Grondelle et al., J. Struct. Biol., 160, 211 (2007) 3. Peptides that regulate food intake: somatostatin alters intake of amino acid-imbalanced diets and taste buds of tongue in rats. G.Scalera, Am. J. Physiol. Regul. Integr. Comp. Physiol., 284, R1389 (2003) 4. Changes in thymus size, cellularity and relation between thymocyte subpopulations in young adult rats induced by somatostatin-14. D.M.Petrovic-Dergovic et al., Neuropeptides, 41, 485 (2007) 5. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. P.Brazeau et al., Science, 179, 77 (1973) 6. Somatostatin-14 influences pituitary-ovarian axis in peripubertal rats. N.Nestorovic et al., Histochem. Cell Biol., 130, 699 (2008) 7. Somatostatin and growth hormone releasing factor: synthesis, location, metabolism and function. A.Gomez-Pan and M.D.Rodriguez-Arnao, Clin. Endocrinol. Metab., 12, 469 (1983) 8. Positive and negative contractile effects of somatostatin-14 on rat ventricular cardiomyocytes. Murray F, et al. J Cardiovasc Pharmacol. 2001 Mar;37(3):324-32. 9. SRIF receptor subtype expression and involvement in positive and negative contractile effects of somatostatin-14 (SRIF-14) in ventricular cardiomyocytes. Bell D, et al. Cell Physiol Biochem. 2008;22(5-6):653-64. |