| CAS | 4910-46-7 |
| Sequence | Ac-Asp(Glu-OH)-OH |
| Sequence Single | Ac-D(E) |
| Molecular Formula | C11H16N2O8 |
| Molecular Weight | 304.26 |
| Synonyms | β-NAAG, Ac-β-Asp-Glu-OH |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Di- and Tripeptides |
| Description | β-Spaglumic acid also called β-NAAG, Ac-β-Asp-Glu-OH, is a non-hydrolyzable NAAG isomer. It is a competitive NAAG peptidase inhibitor (Ki=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies. |
| References | 1. Identification of the catalytic triad residues of porcine liver acylamino acid-releasing enzyme. M.Mitta et al., J. Biochem., 123, 924 (1998) 2. N-acetylaspartylglutamate and beta-NAAG protect against injury induced by NMDA and hypoxia in primary spinal cord cultures. Yourick DL, et al. Brain Res. 2003 Nov 21;991(1-2):56-64. 3. β-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor. Wroblewska B, et al. J Neurophysiol. 2001 Mar;85(3):1097-106. |