| CAS | 3106-85-2 |
| Sequence | Ac-Asp-Glu-OH |
| Sequence Single | Ac-DE |
| Molecular Formula | C11H16N2O8 |
| Molecular Weight | 304.26 |
| Synonyms | NAAG, Ac-Asp-Glu |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease|Di- and Tripeptides |
| Description | Spaglumic acid also called NAAG, Ac-Asp-Glu, is an endogenous dipeptide with high affinity for a brain glutamate receptor. Spaglumic acid is the most abundant peptide neurotransmitter in the mammalian central nervous system. |
| References | 1. Phosphorylation of small peptides by spleen TPK-IIA, a tyrosine protein kinase stimulated by polylysine and by high ionic strengthOriginal. A.M.Brunati et al., FEBS Lett., 254, 145 (1989) 2. N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain "glutamate" receptor. R.Zaczek et al., Proc. Natl. Acad. Sci. USA, 80, 1116 (1983) 3. N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J.H.Neale et al., J. Neurochem., 75, 443 (2000) 4. The nagging question of the function of N-acetylaspartylglutamate. Coyle JT. Neurobiol Dis. 1997;4(3-4):231-8. |