| Sequence | Ac-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-γ-Glu-His-Ser-ε-Lys-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2(Cyclized = Glu-28 - Lys-31) |
| Sequence Single | Ac-PPISLDLTFHLLREVLE-Nle-ARAEQLAQQ-γ-Glu-HS-ε-Lys-RKL-Nle-EII-NH2(Cyclized = Glu-28 - Lys-31) |
| Molecular Formula | C203H337N57O56 |
| Molecular Weight | 4472.24 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Stressin I is a potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Stressin I increases ACTH levels and increases faecal pellet output in vivo following i.p. administration. |
| References | 1. Stressin1-A, a potent cortico. releasing factor receptor 1 (CRF1)-selective peptide agonist. Rivier et al (2007). J.Med.Chem. 50 1668 PMID: 17335188 2. CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. Bruchas et al (2009). PLoS One. 4 e8528 PMID: 20052275 |