CAS | 150234-52-9 |
Sequence | H-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-OH |
Sequence Single | SEVNLDAEF |
Molecular Formula | C44H66N10O18 |
Molecular Weight | 1023.07 |
Synonyms | (Asn670,Leu671)-APP770 (667-675), APP770 (667-675) Swedish Mutation, (Asn670, Leu671)-Amyloid β/A4 Protein Precursor770 (667-675) |
Technology | Synthetic |
Storage | -20°C, avoid light, cool and dry place |
Application | Alzheimer’s Disease |
Description | (Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675) also called (Asn670,Leu671)-APP770 (667-675), APP770 (667-675) Swedish Mutation, (Asn670, Leu671)-Amyloid β/A4 Protein Precursor770 (667-675), corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer’s disease, therefore referred to as the ‘Swedish’ mutation (K670N/M671L). The peptide has been used for assaying cleavage at leucine-aspartate by cathepsin G and chymotrypsin, whereas neither cathepsin B, D nor L generated any products. |