| CAS | 350228-37-4 |
| Sequence | H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe-OH |
| Sequence Single | KTEEISEVN-Sta-VAEF |
| Molecular Formula | C73H118N16O27 |
| Molecular Weight | 1651.83 |
| Synonyms | (Asn670,Sta671,Val672)-APP770 (662-675) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease |
| Description | (Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675) also called (Asn670,Sta671,Val672)-APP770 (662-675), represents a potent substrate analog inhibitor of APP β-secretase with IC50 = 30 nM. Amyloid precursor protein (APP) β-secretase from human brain cleaves full-length APP at the amino terminus of the amyloid β-protein (Aβ) sequence, thus leading to the generation and extracellular release of β-cleaved soluble APP and a corresponding cell-associated carboxy-terminal fragment. The subsequent cleavage of the C-terminal fragment by γ-secretase(s) leads to the formation of Aβ. |
(Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675)
CAS No.: 350228-37-4
(Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675) also called (Asn670,Sta671,Val672)-APP770 (662-675),
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