| CAS | 1802078-43-8 |
| Sequence | Abz-Val-Lys-Met-Asp-Ala-Glu-EDDnp |
| Sequence Single | Abz-VKMDAE-EDDnp |
| Molecular Formula | C43H62N12O15S |
| Molecular Weight | 1019.1 |
| Synonyms | JMV2235, Abz-APP770 (669-674)-EDDnp |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Alzheimer’s Disease |
| Description | Abz-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp also called JMV2235, Abz-APP770 (669-674)-EDDnp, is a intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It mimicks the wild-type (JMV2235) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity). This FRET substrate is cleaved by BACE1, BACE2, and cathepsin D. |
Abz-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp
CAS No.: 1802078-43-8
Abz-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp also called JMV2235, Abz-APP770 (669-674)-EDDnp, is a intramolecu
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