| CAS | 352017-71-1 |
| Sequence | H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2 |
| Sequence Single | AYPGKF-NH2 |
| Molecular Formula | C34H48N8O7 |
| Molecular Weight | 680.8 |
| Synonyms | AYPGKFamide, (Ala1)-Proteinase Activated Receptor 4 (1-6) amide (mouse), (Ala1)-Thrombin Receptor-Like 3 (1-6) amide (mouse), (Ala1)-Coagulation Factor II Receptor-Like 3 (1-6) amide (mouse), AYPGKF-NH2 Selective Protease-Activated Receptor 4 (PAR4) Agoni |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases|Hematology |
| Description | (Ala1)-PAR-4 (1-6) amide (mouse) also called AYPGKFamide, (Ala1)-Proteinase Activated Receptor 4 (1-6) amide (mouse), (Ala1)-Thrombin Receptor-Like 3 (1-6) amide (mouse), (Ala1)-Coagulation Factor II Receptor-Like 3 (1-6) amide (mouse), AYPGKF-NH2 Selective Protease-Activated Receptor 4 (PAR4) Agonist, is a peptide based on the proteolytically-revealed tethered ligand sequence of the murine proteinase-activated receptor-4 (PAR-4), it was shown to cause platelet aggregation with an EC50 value of about 15 µM. (Ala1)-PAR-4 (1-6) amide (mouse) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist. |
| References | 1. The aspartimide problem in Fmoc-based SPPS. Part I. M.Mergler et al., J. Pept. Sci., 9, 36 (2003) 2. PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets. R.A.Henriksen and V.K.Hanks, Arterioscler. Thromb. Vasc. Biol., 22, 861 (2002) 3. Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function. T.R.Faruqi et al., J. Biol. Chem., 275, 19728 (2000) 4. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activatedfeed-back loop in visceral inflammatory pain. Annaházi A, et al. Neurogastroenterol Motil. 2012 Jan;24(1):76-85, e13. |
(Ala1)-PAR-4 (1-6) amide (mouse)
CAS No.: 352017-71-1
(Ala1)-PAR-4 (1-6) amide (mouse) also called AYPGKFamide, (Ala1)-Proteinase Activated Receptor 4 (1-6) amide (mouse), (A
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