| CAS | 245443-52-1 |
| Sequence | H-Gly-Tyr-Pro-Gly-Lys-Phe-NH2 |
| Sequence Single | GYPGKF-NH2 |
| Molecular Formula | C33H46N8O7 |
| Molecular Weight | 666.78 |
| Synonyms | GYPGKFamide, Proteinase Activated Receptor 4 (1-6) amide (mouse), Thrombin Receptor-Like 3 (1-6) amide (mouse), Coagulation Factor II Receptor-Like 3 (1-6) amide (mouse), GYPGKF-NH2 Selective Protease-Activated Receptor 4 (PAR4) Agonist |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases|Hematology|Inflammation Research |
| Description | PAR-4 (1-6) amide (mouse) also called GYPGKFamide, Proteinase Activated Receptor 4 (1-6) amide (mouse), Thrombin Receptor-Like 3 (1-6) amide (mouse), Coagulation Factor II Receptor-Like 3 (1-6) amide (mouse), GYPGKF-NH2 Selective Protease-Activated Receptor 4 (PAR4) Agonist, is a protease-activated receptor-4 activating peptide derived from murine PAR-4. PAR-4 (1-6) amide (mouse) was able to cause rat platelet aggregation with an EC50 value of 40 µM. Its effect on leucocyte rolling and adherence points at a role of PAR-4 in mediating proinflammatory processes. |
| References | 1. Quantitative high-performance liquid chromatography-tandem mass spectrometry impurity profiling methods for the analysis of parenteral infusion solutions for amino acid supplementation containing L-alanyl-L-glutamine. S.Schiesel et al., J. Chromatogr. A, 1259, 111 (2012) 2. Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo. N.Vergnolle, J. Immunol., 163, 5064 (1999) 3. Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. M.D.Hollenberg and M.Saifeddine, Can. J. Physiol. Pharmacol., 79, 439 (2001) 4. Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo. N.Vergnolle, J. Immunol., 163, 5064 (1999) |