Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp Secretase Inhibitors and Substrates Catalog

CAS	1007306-20-8
Sequence	Abz-Val-Asn-Leu-Asp-Ala-Glu-EDDnp
Sequence Single	Abz-VNLDAE-EDDnp
Molecular Formula	C42H58N12O16
Molecular Weight	986.99
Synonyms	JMV2236, Abz-(Asn670,Leu671)-APP770 (669-674)-EDDnp
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Alzheimer’s Disease
Description	Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp also called JMV2236, Abz-(Asn670,Leu671)-APP770 (669-674)-EDDnp, is a intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity). This FRET substrate is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2).
References	1. BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors. D.Andrau et al., J. Biol. Chem., 278, 25859 (2003)

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