trans-Stilbene ((E)-Stilbene) may be utilized to make dye lasers, optical brighteners, and non-steroidal synthetic estrogens.

Physicochemical Properties

Molecular Formula	C14H12
Molecular Weight	180.25
Exact Mass	180.093
CAS #	103-30-0
Related CAS #	trans-Stilbene-13C2;153610-50-5;trans-Stilbene-d12;16341-52-9;trans-Stilbene-d10;20748-24-7;trans-Stilbene-d2;5284-44-6
PubChem CID	638088
Appearance	White to off-white solid powder
Density	1.0±0.1 g/cm3
Boiling Point	307.0±0.0 °C at 760 mmHg
Melting Point	123-125 °C(lit.)
Flash Point	128.5±9.7 °C
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.659
LogP	4.83
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	0
Rotatable Bond Count	2
Heavy Atom Count	14
Complexity	149
Defined Atom Stereocenter Count	0
SMILES	C1=CC=C(C=C1)/C=C/C2=CC=CC=C2
InChi Key	PJANXHGTPQOBST-VAWYXSNFSA-N
InChi Code	InChI=1S/C14H12/c1-3-7-13(8-4-1)11-12-14-9-5-2-6-10-14/h1-12H/b12-11+
Chemical Name	(E)-stilbene
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ADME/Pharmacokinetics	Metabolism / Metabolites TRANS-STILBENE GIVES 4-HYDROXY-TRANS-STILBENE IN RABBIT & GUINEA PIG. /FROM TABLE/ STUDY OF RING-HYDROXYLATED METABOLITES OF TRANS-STILBENE /SHOWS/...URINE CONTAINS RANGE OF POLYHYDROXYLATED BIBENZYL DERIVATIVES. ...EVIDENCE /SUGGESTS/ THAT BIBENZYL COMPD ARE FORMED BY MICROFLORAL REDUCTION OF STILBENES. IN GUINEA PIGS & RABBITS, /TRANS-STILBENE/ BIOTRANSFORMATION INTO 4-HYDROXY-, 4,4'-DIHYDROXY-, 3-HYDROXY-4-METHOXY-, & 3-METHOXY-4-HYDROXYSTILBENES OCCURS... HOWEVER, IN MOUSE ONLY LIMITED CONVERSION TO 4,4'-DIHYDROXY- TAKES PLACE. SCHEME FOR OXIDATIVE CLEAVAGE OF ETHYLENIC LINKAGE OF STILBENE IS PRESENTED. For more Metabolism/Metabolites (Complete) data for TRANS-1,2-DIPHENYLETHYLENE (6 total), please visit the HSDB record page.
Toxicity/Toxicokinetics	Non-Human Toxicity Values LD50 Mouse oral 920 mg/kg LD50 Mouse ip 6050 mg/kg
References	[1]. Trans-Stilbenes in Commercial Grape Juices: Quantification Using HPLC Approaches. Int J Mol Sci. 2016 Oct 24;17(10):1769.
Additional Infomation	Trans-stilbene appears as off-white crystals. Melting point of 122-124 °C. Shows blue fluorescence. (NTP, 1992) Stilbene is an olefinic compound and a member of benzenes. trans-Stilbene has been reported in Alnus firma, Paeonia rockii, and other organisms with data available. Organic compounds that contain 1,2-diphenylethylene as a functional group.

Solubility Data

Solubility (In Vitro)

DMSO: 50 mg/mL (277.39 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (13.87 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.5479 mL	27.7393 mL	55.4785 mL
	5 mM	1.1096 mL	5.5479 mL	11.0957 mL
	10 mM	0.5548 mL	2.7739 mL	5.5479 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.