hMcl-1-IN-1 (Compound 9) is a His224 aryl fluorosulfonate-based hMcl-1 inhibitor with an IC50 of 5.8 nM.

Physicochemical Properties

Molecular Formula	C69H113FN20O19S
Molecular Weight	1577.82
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	IC50: 5.8 nM (hMcl-1)[1].
References	[1]. Covalent Targeting of Histidine Residues with Aryl Fluorosulfates: Application to Mcl-1 BH3 MimeticsJ. Journal of Medicinal Chemistry, 2024.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.6338 mL	3.1689 mL	6.3379 mL
	5 mM	0.1268 mL	0.6338 mL	1.2676 mL
	10 mM	0.0634 mL	0.3169 mL	0.6338 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.