cSRC/BCR-ABL-IN-1 (compound 21b) is a potent inhibitor of Bcr-Abl and C-Src with IC50 values of 56.2 and 101 nM for Bcr-Abl and C-Src, respectively. cSRC/BCR-ABL-IN-1 exhibits cytotoxicity.

Physicochemical Properties

Molecular Formula	C29H31CL2N5O4
Molecular Weight	584.49
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Bcr-Abl 56.2 nM (IC50); C-Src 101 nM (IC50)
References	[1]. Disrupted target binding with acryloyl group as potential Bcr-Abl/C-Src dual kinase inhibitor optimization strategies with maintained antitumor activity. Bioorg Med Chem Lett. 2025 Jan 13;119:130105.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7109 mL	8.5545 mL	17.1089 mL
	5 mM	0.3422 mL	1.7109 mL	3.4218 mL
	10 mM	0.1711 mL	0.8554 mL	1.7109 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.