WRN inhibitor 7 (Compound h6) is a WRN inhibitor. WRN inhibitor 7 effectively inhibits the helicase and ATPase activities of WRN (IC50: 9.8 μM and 15.8 μM, respectively). WRN inhibitor 7 can be used for the study of microsatellite instability (MSI) cancers.

Physicochemical Properties

Molecular Formula	C27H23N3O6
Molecular Weight	485.49
CAS #	444780-45-4
SMILES	C(O)(=O)C1=CC=CC(COC2=CC=CC=C2C=C2C(=O)N(CC(NC3=CC=C(C)C=C3)=O)C(=O)N2)=C1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Targeting ATP-binding site of WRN Helicase: Identification of novel inhibitors through pocket analysis and Molecular Dynamics-Enhanced virtual screening. Bioorg Med Chem Lett. 2024 May 15;104:129711.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.0598 mL	10.2989 mL	20.5977 mL
	5 mM	0.4120 mL	2.0598 mL	4.1195 mL
	10 mM	0.2060 mL	1.0299 mL	2.0598 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.